In our group we investigate the excitability of neural and cardiac cells under normal and pathopyhsiological conditions. Mental disorders, hyperalgesia or cardiac arrhythmias often originate from mutations and changes in the activity of ion channels. We use immunocytochemical, molecular biological and electrophysiological methods together with cell culture as heterologous expression system to study cellular signaling pathways which might be involved in the development of diseases of the nervous systems and the heart.